細胞の自己防衛:細胞自律免疫が病原体からどのように保護するか
Felix Randow1, John D MacMicking, Leo C James
1Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, UK. randow@mrc-lmb.cam.ac.uk
まとめ
免疫細胞だけでなく,ほとんどの細胞は,細胞自律免疫を通して感染から防御することができます. この古代の防御メカニズムは,すべての生命領域で機能し,細胞内構造を防御のために利用します.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 微生物学 微生物学とは
背景:
- 宿主防衛の伝統的な見解は,特化した免疫細胞に焦点を当てています.
- この視点では,非免疫細胞の抗菌剤耐性能力が無視されている.
- 細胞自律免疫は,生命のあらゆる領域に存在する基本的な防御機構です.
研究 の 目的:
- ホスト防衛の従来の理解に挑戦するために.
- 細胞自律免疫の重要性を強調するために.
- 細胞の自己防衛機構を支配する原理を探求する.
主な方法:
- ホストの防御と細胞免疫に関する既存の文献のレビュー.
- 抗菌剤耐性における細胞内分割の役割の分析.
- 細胞自律免疫の進化的起源と普遍性についての議論.
主要な成果:
- ほとんどの細胞系は,固有の抗微生物防御能力を持っています.
- 細胞自律免疫は,宿主保護の古くから広く普及している形態です.
- 細胞内分割は,病原体に対する細胞の効果的な自己防衛に不可欠です.
結論:
- 脊椎動物の宿主防御は,特化した免疫細胞以上のものに依存しています.
- 細胞自律免疫は,宿主保護の重要な,しかし過小評価された層を表しています.
- 細胞の自己防衛機構を理解することは,微生物感染と闘うための新しい洞察を提供します.
関連する概念動画
Cell-mediated Immune Responses
Overview
Introduction to Innate and Adaptive Immunity
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Phagocytes
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Phagocytes
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Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

