心の底から若い
Leslie A Leinwand1, Brooke C Harrison
1Department of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA. leslie.leinwand@colorado.edu
Cell
|May 14, 2013
まとめ
若いマウスの血液循環は,老いたマウスの心筋縮を逆転させることができます. この効果は,年老いたマウスを成長分化因子11 (GDF11) で治療することで再現され,年齢関連の心臓病に対するGDF11療法が示唆されています.
科学分野:
- ゲロントロジーと再生医療
- 心血管生物学 心血管生物学
背景:
- 老化は,心筋縮を含む心臓の構造と機能の有害な変化と関連しています.
- 年齢関連の心筋縮は,心臓の機能を低下させ,心血管疾患のリスクを高めます.
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