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Updated: May 11, 2026

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
08:04

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

mTORC1経路は,SIRT4を抑制することによってグルタミン代謝と細胞増殖を刺激する

Alfred Csibi1, Sarah-Maria Fendt, Chenggang Li

  • 1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|May 14, 2013
PubMed
まとめ

ラパミシン複合体1 (mTORC1) の哺乳類標的は,グルタミン脱水素酶 (GDH) の主要な調節体であるSIRT4を阻害することによってグルタミン代謝を活性化します. この経路は癌において極めて重要であり,新たな治療目標を示唆している.

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