非心臓外科手術後の心筋梗塞の損傷と短期死亡率との関連
Judith A R van Waes1, Hendrik M Nathoe, Jurgen C de Graaff
1Department of Anesthesiology, University Medical Center Utrecht, Local Mail Q04.2.313, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
Circulation
|May 14, 2013
まとめ
トロポニン上昇によって検出される術後心筋損傷は,非心臓手術患者の30日間の死亡率を独立して予測します. 定期的なトロポニンモニタリングは,患者のアウトカムを改善する可能性があります.
科学分野:
- 心臓病学 心臓病学
- 周術医療 (Perioperative Medicine) とは,外科手術の際の治療法である.
- クリニカル診断士
背景:
- 常規の心臓トロポニンモニタリングは,心臓外科手術後の死亡リスクのある患者を特定するために提案されています.
- この研究では,30日間の死亡率に対するトロポニン上昇の予測価値を評価した.
研究 の 目的:
- トロポニン濃度によって示される術後の心筋損傷が,非心臓手術後の30日間の死亡率を予測するかどうかを判断する.
- トロポニンモニタリングを標準的なケアとして実施する可能性と有用性を評価する.
主な方法:
- 観察的,単一センターコホート研究で,60歳以上の中間から高リスクの非心臓外科手術患者の2232人を対象に実施した.
- トロポニンIレベルは,手術後の最初の3日間で測定されました.
- ログバイノミアル回帰では,トロポニン値上昇 (>0.06μg/L) と全原因30日間の死亡率との関連を分析した.
主要な成果:
- 術後の心筋損傷は,患者の19% (315/1627) で検出されました.
- すべての原因による30日間の死亡率は,患者の3%で発生した (56/2232).
- トロポニンの濃度の上昇は,30日間の死亡リスクを大幅に増加させた (RR2.4は軽度の上昇,RR4.2は重度の上昇).
結論:
- 術後の心筋損傷は,非心臓手術後の30日間の死亡率の独立した予測因子です.
- 定期的なトロポニンモニタリングを実施することは実行可能であり,患者の予後を改善するのに役立ちます.
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