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Updated: May 11, 2026

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima
09:13

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima

Published on: August 12, 2018

ミトコンドリアのゲートキーパーであるピルバート脱水素酵素が,腫瘍遺伝子誘発の衰老において重要な役割を果たしている

Joanna Kaplon1, Liang Zheng, Katrin Meissl

  • 1Division of Molecular Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Nature
|May 21, 2013
PubMed
まとめ

腫瘍遺伝子の誘発性老化 (OIS) は,細胞増殖を停止することによって癌を予防します. この研究は,ピルバート脱水素酶 (PDH) がOISの鍵であり,代謝とがん抑制を結びつけ,メラノーマの新たな治療標的を提供することを明らかにしています.

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