分子内シュミット反応の触媒における製品阻害を克服する

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Updated: May 11, 2026

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
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Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

Hashim F Motiwala1, Charlie Fehl, Sze-Wan Li

  • 1Department of Medicinal Chemistry, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, West Campus, Lawrence, Kansas 66047, USA.

Journal of the American Chemical Society
|May 22, 2013
PubMed
まとめ

この研究は,アルキルアジドとケトンのための改善された内分子シュミット反応を導入します. ヘクサフッロロ-2-プロパノールを溶媒として使用することで,シブソイヒオメトリック触媒の負荷が加えられ,反応の効率が向上します.

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