人間の皮膚における真菌および細菌の群れの地形学的多様性
Keisha Findley1, Julia Oh, Joy Yang
1Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Nature
|May 24, 2013
まとめ
人間の皮膚には様々な真菌が宿っており,体と比べると足には独特のコミュニティがあります. これらの真菌のコミュニティを理解することは,皮膚疾患の診断と治療に不可欠です.
科学分野:
- 微生物学 微生物学とは
- ゲノミクスゲノミクスとは
- 皮膚科 皮膚科について
背景:
- 伝統的な方法は,アスリートの足のような真菌性皮膚疾患を不完全に定義しています.
- ゲノム学的アプローチはバクテリアの研究を進めてきたが,真菌については遅れをとっている.
- 菌類は,微生物コミュニティの安定性,健康,および病気において重要な役割を果たします.
研究 の 目的:
- 人間の皮膚の様々な部位に広がる真菌のコミュニティを特徴づけること.
- 健康な体部位と足部位の真菌の多様性を比較する.
- 細菌と真菌の皮膚微生物の相互作用を調査する.
主な方法:
- 10人の健康な成人の14の皮膚部位から真菌コミュニティの配列と分析.
- 菌類種の識別のための系統遺伝マーカー分析.
- バクテリアと真菌の共同体の同時分析.
主要な成果:
- 身体と腕の部位は,マラスゼジア菌によって支配され,種レベルでの部位特有の違いがありました.
- 足の部位 (脚の足底部,足の爪,足の爪網) は,高いキノコの多様性を示した.
- 皮膚の生理学と地形は,細菌や真菌のコミュニティに差異的に影響を与えます.
結論:
- 人間の皮膚には多様な真菌のコミュニティがあり,足にはユニークな微生物の風景が描かれています.
- サイト特有の真菌の多様性は,皮膚の健康と病気を理解するための意味を持っています.
- 菌類と細菌のコミュニティの相互作用は,皮膚のホメオスタシスと病原性の鍵です.
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