BAF複合体は,トポイソメラーゼIIαによるDNAの解鎖を促進する

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Updated: May 3, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

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Emily C Dykhuizen1, Diana C Hargreaves, Erik L Miller

  • 1Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature
|May 24, 2013
PubMed
まとめ

人間の癌の20%以上で変異したBAF複合体は,細胞分裂中のDNAの解鎖に不可欠です. トポイソメラーゼIIαとの相互作用により,染色体分離の誤差を防止し,腫瘍抑制作用を強調する.

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