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Updated: May 11, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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保存された長寿メカニズムとしてのミト核タンパク質の不均衡

Riekelt H Houtkooper1, Laurent Mouchiroud, Dongryeol Ryu

  • 1Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

Nature
|May 24, 2013
PubMed
まとめ

ミトコンドリアのリボソームタンパク質 (Mitochondrial ribosomal proteins, MRP) は,核タンパク質とミトコンドリアのタンパク質のバランスを制御することによって長寿を調節する. このバランスを破壊すると,種全体で保存されている重要な長寿経路が活性化します.

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