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Updated: May 11, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
08:10

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

サイトメガロウイルスベクターは,CD8+T細胞の表皮質認識パラダイムに違反します

Scott G Hansen1, Jonah B Sacha, Colette M Hughes

  • 1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

Science (New York, N.Y.)
|May 25, 2013
PubMed
まとめ

Simian immunodeficiency virus (SIV) のタンパク質発現するレサス・サイトメガロウイルス (RhCMV) ベクトルは,さまざまなCD8 (((+)) T細胞応答を誘発する. これらのサイトメガロウイルス (CMV) ベクトルの遺伝的プログラミングは,免疫を改善するためにT細胞の表皮質認識パターンを制御することができます.

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