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Updated: May 11, 2026

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
11:37

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Published on: November 29, 2013

アミドからエステルへの変異によってタンパク質-ペプチド相互作用における骨幹水素結合の役割を探求する

Jonas N N Eildal1, Greta Hultqvist, Thomas Balle

  • 1Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Journal of the American Chemical Society
|May 28, 2013
PubMed
まとめ

脊髄水素結合は,リンガンドが,ポストシナプス密度95/ディスク大/ゾヌラオクラデンス1 (PDZ) ドメインに結合する際に極めて重要です. これらの結合を混乱させると,結合親和性が著しく影響され,タンパク質-ペプチド相互作用におけるその重要性が明らかになる.

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