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Updated: May 11, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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KAT5 ティロシンリン酸化カップルは,ATM シグナル伝達に染色体センシングを感知します

Abderrahmane Kaidi1, Stephen P Jackson

  • 1The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

Nature
|May 28, 2013
PubMed
まとめ

DNA損傷の検出には,KAT5 (TIP60とも呼ばれる) ティロシンリン酸化が関与し,H3K9me3.3.に結合することを強化します. この変異はATMキナーゼを活性化し,DNA損傷シグナル伝達と細胞生存を促進します.

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