前頭前皮質の2つのインターニューロンタイプの異なる行動およびネットワークの相関関係

D Kvitsiani¹, S Ranade, B Hangya

¹Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

Nature

|May 28, 2013

まとめ

脳内のパーバルブミン (PV) とソマトスタチン (SOM) のニューロン

科学分野:

神経科学は神経科学である.
細胞生物学細胞生物学
計算神経科学とは

背景:

前頭前皮質の神経細胞は,細胞タイプの違いによる可能性のある多様な行動的役割を示しています.
ニューロンの種類を理解することは,ネットワーク機能と行動を結びつけるための鍵です.

研究の目的:

前帯状皮質におけるパルバルブミン (PV) とソマトスタチン (SOM) 内ニューロンの異なる役割を,報酬の採取作業中に調査する.
これらの特定のニューロンタイプが,採食行動における意思決定プロセスにどのように貢献するかを決定する.

主な方法:

ネズミの遺伝子識別されたPVおよびSOMニューロンからの電気生理学的記録が,報酬の餌を採取するタスクを実行しています.
報酬の接近と離れるような特定の行動イベントに関連したニューロン活動の分析.
主細胞に対するPVおよびSOMニューロンの抑制効果の特徴.

主要な成果:

PVとSOMニューロンのサブタイプは,行動と抑制において,区別され,分離された役割を示した.
SOMニューロンは報酬の接近時に選択的に反応し,PVニューロンは報酬の離脱時に反応し,前回の滞在期間をエンコードしました.
PVニューロンは迅速で強力な阻害を行使し,SOMニューロンはより弱く,より変数の抑制効果を持っていた.

結論:

PVとSOMのインターニューロンサブタイプは,情報フローの調節と採食中の意思決定において,機能的に異なる役割を果たします.
細胞型の多様性は,行動中の皮質回路で観察される機能的多様性に大きく貢献します.
これらの発見は,特定のインターニューロンクラスを,採食と意思決定における前帯状皮質の重要な機能と関連付けています.

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