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Updated: May 5, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

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Published on: September 18, 2014

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cGASは,STINGを活性化させる2'-5'-リンクされたサイクルダイヌクレオチドセカンドメッセンジャーを生成します

Andrea Ablasser1, Marion Goldeck, Taner Cavlar

  • 1Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany. andrea.ablasser@uni-bonn.de

Nature
|June 1, 2013
PubMed
まとめ

サイクルGMP-AMP合成酵素 (cGAS) は,新しいサイクルディヌクレオチドであるcGAMPを生成し,STINGタンパク質を活性化します. 独特の2-5結合を特徴とするこの分子は,DNAに対する先天的な免疫反応に不可欠です.

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