Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Vaccinations01:51

Vaccinations

Overview

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell Receptors.

Research square·2026
Same author

Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell Receptors.

bioRxiv : the preprint server for biology·2026
Same author

CD8<sup>+</sup> T cell stemness precedes post-intervention control of HIV viraemia.

Nature·2025
Same author

CD8<sup>+</sup> T cell recall cytotoxicity during chronic treated HIV-1 infection is associated with limited reservoir size and activity.

medRxiv : the preprint server for health sciences·2025
Same author

Guidelines for T cell nomenclature.

Nature reviews. Immunology·2025
Same author

Bayesian estimation of HIV acquisition dates for prevention trials.

mBio·2025

関連する実験動画

Updated: May 11, 2026

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development
09:03

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

グローバルな疾病予防のための次世代ワクチンの開発を加速する.

Wayne C Koff1, Dennis R Burton, Philip R Johnson

  • 1International AIDS Vaccine Initiative (IAVI), New York, NY 10004, USA. wkoff@iavi.org

Science (New York, N.Y.)
|June 1, 2013
PubMed
まとめ

エイズ,結核,マラリアなどの病気に対するワクチンの開発には,新しい戦略が必要です. 人間の免疫学を理解することは,これらの挑戦的な世界的な健康上の脅威に対する効果的なワクチンの作成の鍵です.

さらに関連する動画

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles
10:16

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles

Published on: August 17, 2022

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

関連する実験動画

Last Updated: May 11, 2026

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development
09:03

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles
10:16

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles

Published on: August 17, 2022

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

科学分野:

  • 免疫学 免疫学とは
  • ワクチン学 ワクチン学
  • 公衆衛生は公衆衛生である.

背景:

  • ワクチンは公衆衛生の礎石ですが,従来の方法は複雑な病気で課題に直面しています.
  • エイズ,結核,マラリアなどの主要な世界的な病気は,保護メカニズムと病原体の多様性の理解が不十分であるため,ターゲットにすることが困難です.
  • 既存のワクチン開発戦略は,これらの複雑な病原体に対して不十分です.

研究 の 目的:

  • ワクチンの発見における最近の進歩をレビューする.
  • ヒトワクチン学の理解を深める必要性を強調する.
  • 効果的なワクチン開発のための新しい研究イニシアチブを提案する.

主な方法:

  • ワクチンの発見とヒト免疫学に関する最近の科学文献のレビュー.
  • エイズ,結核,マラリアに対するワクチンの開発における課題の分析.
  • ヒト免疫学に基づく臨床研究の重要性を議論する.

主要な成果:

  • 最近の科学的進歩は,ワクチンの発見のための新しい道を提供します.
  • ヒトにおける重要なワクチン学原理の理解には大きなギャップが存在します.
  • 現在のアプローチは,定義されていない保護の相関値と高い変動性を持つ病原体に対するワクチンの開発には不十分です.

結論:

  • 世界の主要な病気に対するワクチンの開発を加速するには,戦略の転換が必要である.
  • ヒト免疫学に焦点を当てた新しい臨床研究イニシアチブが不可欠です.
  • ヒトにおけるワクチンの誘発による保護性免疫反応の解明と強化は,将来の成功にとって極めて重要です.