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システミック・ルプス・エリテマトーサスにおける心臓異常. アソシエーションは,抗カルディオリピン抗体の上昇と関連しています
P Nihoyannopoulos1, P M Gomez, J Joshi
1Department of Medicine, Hammersmith Hospital, London, UK.
Circulation
|August 1, 1990
まとめ
高濃度のアンチカルディオリピン抗体は,全身性白血球性狼 (SLE) 患者における心臓異常と強く関連しています. エコーカルディオグラフィでは,SLE患者で抗体が上昇した際に,弁損傷,心周問題,左心室機能不全が明らかになった.
科学分野:
- 心臓病学 心臓病学
- レウマトロジーの病理学
- 免疫学 免疫学とは
背景:
- システミック・ルプス・エリテマトーサス (SLE) は,潜在的に心的症状を持つ自己免疫疾患である.
- アンチカルディオリピン抗体は,SLEで頻繁に観察され,血栓性イベントと関連しています.
研究 の 目的:
- SLE患者における心臓異常の発生率とスペクトルを決定する.
- SLEにおける心臓の発見と高抗カルディオリピン抗体レベルとの関連を調査する.
- SLEのない抗カルディオリピン抗体が上昇した個体における心臓異常を評価する.
主な方法:
- 93人のSLE患者を対象とした二次元エコーカルディオグラフィー研究.
- イントラカルディアック解剖学的評価は,抗カルディオリピン抗体が上昇した12人の追加の患者で,SLEではない.
- 心臓異常と抗カルディオリピン抗体レベルとの相関分析.
主要な成果:
- SLE患者の54%は,弁の病変 (28%), perikardial effusion/thickening (20%) および左心室機能不全 (5%) を含む心臓異常を有していました.
- SLE患者の54%に高レベルの抗カルディオリピン抗体が存在し,そのうち78%が心臓異常を患っていた.
- 増加した抗カルディオリピン抗体は,SLEにおける心臓異常と強く関連していました (p < 0.0001),78%の感度と74%の特異性がありました.
結論:
- 高濃度の抗カルディオリピン抗体レベルは,SLE患者における心臓異常の有意な予測因子である.
- SLEと同様の心異常は,SLEの分類基準を満たしていない抗心臓リピン抗体が上昇した個体でも観察されました.
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