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関連する概念動画

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...

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関連する実験動画

Updated: May 10, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

ダイナミック・コンビナトリアル・ライブラリ: 分子認識の探索からシステム化学まで

Jianwei Li1, Piotr Nowak, Sijbren Otto

  • 1Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Journal of the American Chemical Society
|June 5, 2013
PubMed
まとめ
この要約は機械生成です。

ダイナミック・コンビネトリアル・ケミストリー (DCC) は,相互変換する分子を利用して,自己複製器のような新しい構造を発見します. このアプローチ,ダイナミック・コンビネトリアル・ライブラリ (DCL) は,システム化学と分子機械の新たな道を開く.

さらに関連する動画

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

関連する実験動画

Last Updated: May 10, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

科学分野:

  • 化学 化学は化学です.
  • 超分子化学 超分子化学
  • システム化学 システム化学

背景:

  • ダイナミック・コンビネトリアル・ケミストリー (DCC) は,メンバーが継続的にビルディングブロックを交換するライブラリを含む.
  • ダイナミック・コンビネトリアル・ライブラリ (DCL) は,予期せぬ分子構造と機能を発見する鍵となるものです.
  • DCLは,分子ネットワークの新興特性を可能にし,システム化学の新たな可能性を開きます.

研究 の 目的:

  • ダイナミック・コンビネトリアル・ケミストリーにおける新しい方法論を強調する.
  • 合成および自己組み立てにおけるアプリケーションのために,熱力学的制御下でDCLを分析する.
  • DCCの原則を非均衡システムに拡張して,高度な機能を適用することを検討する.

主な方法:

  • 化学図書館メンバーのダイナミックな相互変換の探索.
  • ダイナミック・コンビナトリアルライブラリの熱力学制御.
  • DCCの原則を非均衡システムに適用する.

主要な成果:

  • 相互に繋がった構造や自己複製器を含む新種の分子を発見した.
  • 合成受容体,触媒システム,および超分子構造物の開発.
  • 自己複製や分子機械などの非均衡系におけるより豊かな機能的行動の実証.

結論:

  • DCLは,分子発見とシステム化学のための強力なツールです.
  • DCLにおける熱力学的制御は,多様な機能的システムを生み出します.
  • DCCを非均衡システムに拡張することで,高度な分子機能が解き放たれます.