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Updated: May 10, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
11:31

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella

Published on: November 30, 2018

NLRC4の結晶構造は,その自己抑制メカニズムを明らかにしています

Zehan Hu1, Chuangye Yan, Peiyuan Liu

  • 1School of Life Sciences, Tsinghua University, and Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.

Science (New York, N.Y.)
|June 15, 2013
PubMed
まとめ

NLRC4のような核酸結合およびオリゴメリゼーションドメイン型受容体 (NLR) タンパク質は,新しい自己抑制メカニズムを使用します. これは,ドメイン間の相互作用を伴い,特定の信号が活性化を誘発するまで,NLRC4を無効にします.

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An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions

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Allosteric Proteins-ATCase01:19

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...