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Updated: May 10, 2026

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C
11:53

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

Published on: June 1, 2018

アスコルビン酸は,テト媒介の5メチルサイトシン酸化を強化し,哺乳類のDNA脱メチル化を促進する

Ruichuan Yin1, Shi-Qing Mao, Bailin Zhao

  • 1The State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Journal of the American Chemical Society
|June 18, 2013
PubMed
まとめ

アスコルビン酸 (ビタミンC) は,テト酵素の活性を直接強化し,DNA脱メチル化を促進します. この重要な栄養素は,共同因子として作用し,発達や病気に不可欠なDNAの改変に影響を与えます.

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