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Updated: May 10, 2026

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants
07:44

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants

Published on: May 22, 2020

MeCP2スレオニン308の活性依存型リン酸化は,NCoRとの相互作用を調節する

Daniel H Ebert1, Harrison W Gabel, Nathaniel D Robinson

  • 1Department of Neurobiology, Harvard Medical School, and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Nature
|June 18, 2013
PubMed
まとめ

レット症候群 (RTT) は,メチル-CpG結合タンパク質2 (MeCP2) 変異と関連しています. T308でのMeCP2の活性依存型リン酸化は,遺伝子発現と共抑制剤との相互作用を調節し,その喪失はRTTを引き起こす可能性があります.

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