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ガン細胞における誘導合成致死性の分子標的としてのG四重複DNA

Keith I E McLuckie1, Marco Di Antonio, Heather Zecchini

  • 1Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, United Kingdom.

Journal of the American Chemical Society
|June 21, 2013
PubMed
まとめ

ピリドスタチン (PDS) 薬は,G-四重複素 (G4s) を安定させることで,癌細胞死亡を高める. この合成的致死性アプローチは,DNA修復阻害剤や,DNA修復経路が欠陥のある細胞と組み合わせると有望であることが示されています.

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