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Updated: May 10, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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肥満に起因する腸内微生物の代謝物質は,老化シクレトームを通して肝がんを促進します

Shin Yoshimoto1, Tze Mun Loo, Koji Atarashi

  • 1Division of Cancer Biology, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550, Japan.

Nature
|June 28, 2013
PubMed
まとめ

肥満は,デオキシコール酸 (DCA) を産生する腸内細菌を通じて肝臓がんを促進し,これは肝臓細胞における老化関連分泌フェノタイプ (SASP) を引き起こす. DCAまたはSASPをブロックすると,肥満マウスのがん発症を防ぐことができます.

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