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母親の慢性疾患と先天性心疾患との関連:人口ベースのコホート研究
Shiliang Liu1, K S Joseph, Sarka Lisonkova
1Centre for Chronic Disease Prevention, Public Health Agency of Canada, Room 405A2, AL 8604A, 785 Carling Ave, Ottawa, ON, Canada K1A 0K9. sliu@uottawa.ca
Circulation
|July 2, 2013
まとめ
糖尿病,高血圧,先天性心疾患などの母性疾患は,乳児における先天性心不全 (CHD) のリスクを大幅に高めます. この集団ベースの研究は,CHDの主要なリスク要因を強調しています.
科学分野:
- 心臓病学 心臓病学
- 妊産婦・胎児医学について
- 公衆衛生は公衆衛生である.
背景:
- 生まれながらの心不全 (CHD) は,幼児の健康における重要な懸念事項です.
- 母親の健康と乳児のCHDの関連性を理解することは,予防と早期介入において極めて重要です.
研究 の 目的:
- 母親の病状と乳児における心血管疾患の発生との関連を定量化するために.
- CHDのリスクを高める特定の母性疾患を特定する.
主な方法:
- カナダ (2002年−2010年) の220万人を超える母と乳児のペアを分析した人口ベースの研究です.
- 乳児の心臓病は,疾病および関連する健康問題に関する国際統計分類,第10版,カナダのコードを使用して分類されました.
- 関連性を評価するために,母性の要因に調整されたロジスティック回帰モデルが使用されました.
主要な成果:
- 総合的なCHDの罹患率は,1万生児につき116.2人であった.
- 心臓病のリスクの増加と有意に関連した母性疾患には,多胎妊娠,糖尿病 (1型および2型),高血圧,甲状腺疾患,母性先天性心疾患,結合組織疾患,および/気分障害が含まれています.
- 母親の年齢40歳以上も,注目に値するリスク因子でした.
結論:
- 糖尿病,高血圧,結合組織疾患,既にある先天性心疾患などの慢性的な母性疾患は,子孫における心血管疾患のより高いリスクと関連しています.
- これらの発見は,乳児のCHDを予防するために,母親の健康管理の重要性を強調しています.
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