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Updated: May 10, 2026

Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function
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Published on: November 4, 2016

mTORC1は免疫信号と代謝プログラミングを組み合わせて,T ((reg)) 細胞の機能を確立します

Hu Zeng1, Kai Yang, Caryn Cloer

  • 1Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Nature
|July 2, 2013
PubMed
まとめ

ラパミシン複合体1 (mTORC1) 信号伝達のメカニスティックターゲットは,T細胞 (Treg) 機能の調節に極めて重要です. mTORC1を阻害すると,Treg抑制活性が低下し,マウスでは致命的な炎症を引き起こします.

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