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Updated: May 10, 2026

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C
11:53

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

Published on: June 1, 2018

ビタミンCは,テト依存型DNA脱メチル化と,ES細胞におけるブラストシストのような状態を誘発する

Kathryn Blaschke1, Kevin T Ebata, Mohammad M Karimi

  • 1Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Obstetrics and Gynecology and Center for Reproductive Sciences, University of California San Francisco, San Francisco, California 94143, USA.

Nature
|July 2, 2013
PubMed
まとめ

ビタミンCは,十一転位 (Tet) 酵素活性を直接強化し,5-ヒドロキシメチルサイトシン (5hmC) レベルを上昇させ,マウスの胚性幹細胞におけるDNA脱メチル化を促進し,その結果,表遺伝的忠誠性を維持する.

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Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange

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Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase10:33

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

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