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The Extracellular Matrix01:42

The Extracellular Matrix

65.0K
Overview
65.0K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K
The Extracellular Matrix01:29

The Extracellular Matrix

10.7K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
10.7K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.0K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K
Extracellular Matrix01:26

Extracellular Matrix

5.9K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.9K

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関連する実験動画

Updated: May 5, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

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細胞外パズルのピースをまとめる

Daniel J Leahy1

  • 1Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. dleahy@jhmi.edu

Cell
|July 6, 2013
PubMed
まとめ
この要約は機械生成です。

研究者は,細胞外タンパク質の相互作用を特定するための新しい高通量アッセイを開発しました. この方法により,ドロソフィラの多くの新しい相互作用が発見され,タンパク質の相互作用の研究が進められました.

さらに関連する動画

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

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Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans
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Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans

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関連する実験動画

Last Updated: May 5, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

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Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans
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科学分野:

  • バイオケミストリー バイオケミストリー
  • ゲノミクスゲノミクスとは
  • プロテオミクス プロテオミクスは,プロテオミクスの

背景:

  • タンパク質の相互作用を特定することは,細胞の機能を理解するために極めて重要です.
  • 現在の大規模スクリーニング方法は,真核細胞外タンパク質に対して非効率です.

研究 の 目的:

  • 細胞外タンパク質の相互作用を特定するための高通量アッセイを開発する.
  • ドロソフィラの3つのスーパーファミリー内の新しいタンパク質の相互作用を特定する.

主な方法:

  • 新しい高通量スクリーニングアッセイの開発.
  • Drosophila.のタンパク質相互作用を研究するためにアッセイの適用.

主要な成果:

  • このアッセイは,多くの新しい細胞外タンパク質の相互作用を成功裏に特定しました.
  • ドロソフィラの3つの主要なタンパク質スーパーファミリーの間で新しい相互作用が発見されました.

結論:

  • 開発されたアッセイは,細胞外タンパク質の相互作用の大規模な識別に有効です.
  • この研究は,ドロソフィラのタンパク質相互作用のより包括的なスクリーンの基礎を提供します.