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Updated: May 9, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

新しい原始体におけるPtpn11の欠失は,ヘッジホッグのシグナル伝達を誘導することによって,メタコンドロマトーシスを引き起こします

Wentian Yang1, Jianguo Wang, Douglas C Moore

  • 1Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, Rhode Island 02903, USA. wyang@lifespan.org

Nature
|July 19, 2013
PubMed
まとめ

タイロシンフォスファタゼSHP2 (PTPN11でコードされる) は,他の細胞における役割とは異なり,軟骨における腫瘍抑制剤として作用する. 特定の原始細胞におけるSHP2の喪失は,FGFR/MEK/ERKのシグナリングを妨害することによって,メタコンドロマトーシスを引き起こします.

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