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Updated: May 9, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

スパイロリングの形成は,austinol生物合成における多機能ダイオキシゲナーゼによって触媒化されます

Yudai Matsuda1, Takayoshi Awakawa, Toshiyuki Wakimoto

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|July 20, 2013
PubMed
まとめ

研究者らは,メロテルペノイドであるオースティンオールの真菌生物合成を解明した. 多機能ダイオキシゲナーゼ (AusE) を含む主要な酵素は,そのユニークなスパイロラクトン環系のステレオ特異的形成を触媒化する.

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