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Updated: May 5, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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SET1とp300は,結合ヒストンの改変によって,p53による転写活性化において,相乗的に作用する

Zhanyun Tang1, Wei-Yi Chen, Miho Shimada

  • 1Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.

Cell
|July 23, 2013
PubMed
まとめ

SET1複合体 (SET1C) とp300は,ヒストンH3のアセチル化とトリメチル化を改変することによって,遺伝子転写を強化するために協力します. このメカニズムは,特にDNA損傷後に,p53媒介の遺伝子調節に極めて重要です.

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