心臓と肺の共同発達の調整は,多効力のある心肺原始体によって行われます
Tien Peng1, Ying Tian, Cornelis J Boogerd
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Nature
|July 23, 2013
まとめ
研究者らは,心臓における新たな多能性心肺前駆体 (CPPs) を発見した. これらの細胞は,地上の適応に不可欠な心血管と肺系の発達を指揮する.
科学分野:
- 発達生物学 発達生物学について
- 進化生物学の進化生物学について
- 心血管科学と肺科学について
背景:
- 心血管系と肺系の共同発達は,陸上の生命にとって重要な進化的適応である.
- この適応は,心臓の出力を肺のガス交換機能と結びつける.
研究 の 目的:
- 心臓と肺の共同発達に責任を負う原始細胞を特定する.
- これらの祖先の規則と系統の貢献を理解するために.
主な方法:
- ネズミのモデルでの系統追跡とクローン分析を活用した.
- 先祖細胞における遺伝子発現マーカー (Wnt2,Gli1,Isl1) を研究した.
- 前腸内皮からシグナルを送るヘッジホッグの役割を調べた.
主要な成果:
- 心臓の裏極でWnt2,Gli1,Isl1を発現する多効性心肺前駆体 (CPPs) が確認されました.
- CPPは肺発達の前に発生し,心臓および肺の中皮系に寄与することを示した.
- エッジホッグのシグナル伝達が,肺血管系と心臓の接続に不可欠であることを示した.
結論:
- 多能性心肺原始体 (CPPs) の新しい集団は,心臓と肺の共同発達を調整する.
- これらのCPPは,陸上の存在に適応する上で極めて重要です.
- CPPの理解は,心肺系の進化的発展についての洞察を提供します.
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