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Updated: May 9, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
10:51

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

Rac-[Ru(phen) 2dppz]2+とd(ATGCAT) 2のX線結晶構造は,エナティオメルの方向性と水の順序を示しています

James P Hall1, Daniel Cook, Sara Ruiz Morte

  • 1Chemistry Department, University of Reading, Whiteknights, Reading RG6 AD, United Kingdom.

Journal of the American Chemical Society
|July 24, 2013
PubMed
まとめ

この研究は,原子解像度のX線結晶学で可視化されたDNAとルテニウムエナントイオマーの明確な結合方向性を明らかにしています. この発見は,エナチオセレクティブの薬物-DNA相互作用に関する洞察を提供します.

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Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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The naming of enantiomers employs the Cahn–Ingold–Prelog rules that involve assigning priorities to different substituent groups at a chiral center. Each enantiomer, being a distinct molecule, is assigned a unique name by the Cahn–Ingold–Prelog (CIP) rules, also called the R–S system. The prefix R- or S- attached to the chiral centers in an enantiomer is dependent on the spatial arrangement of the four substituents on the chiral center. The R–S system essentially comprises three steps:...
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