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統合的ゲノミクスは,アルツハイマー病のAPOE ε4エフェクターを特定しています

Herve Rhinn1, Ryousuke Fujita, Liang Qiang

  • 1Department of Pathology, Columbia University, 650 W. 168th Street, New York, New York 10032, USA.

Nature
|July 26, 2013
PubMed
まとめ

APOE4や老化などの遺伝的要因は,アルツハイマー病のリスクに影響します. この研究は,アミロイド前駆タンパク質の代謝に影響を与えるAPOE4に関連した分子経路を特定し,LOADを促進するメカニズムを示唆しました.

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