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Updated: May 9, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

H(4) オクタパ-トラストズマブ: 111Inと177Luのイメージングと治療のための汎用性のあるアサイクロンケラート系

Eric W Price1, Brian M Zeglis, Jacqueline F Cawthray

  • 1Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, Canada, V6T 1Z1.

Journal of the American Chemical Society
|August 2, 2013
PubMed
まとめ

新しい二機能ケレーターであるp-SCN-Bn-H4octapaが合成され,標的がん治療のためにトラストズマブと結合されました. このH4octapa-trastuzumabコンジュガートは,DOTA-trastuzumabと比較して,放射性標識とインビオ性能の改善を示しています.

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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies09:29

The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies

Published on: February 12, 2015

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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...