一卵性双生児と二卵性双生児の先天性心不全の有病率の増加
Anne Maria Herskind1, Dorthe Almind Pedersen, Kaare Christensen
1Department of Pediatrics, Hans Christian Andersen Children's Hospital at Odense University Hospital, Odense (A.M.H.); The Danish Twin Registry, University of Southern Denmark, Odense (D.A.P., K.C.); and Departments of Clinical Genetics and Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense C (K.C.), Denmark.
Circulation
|August 10, 2013
まとめ
生まれながらの心不全は,シングルよりも双子に多く見られる. この増加したリスクは,独角性双生児だけでなく,すべての双生児に適用され,注意深い心臓診断の必要性を強調しています.
科学分野:
- ペリナトロジー (Perinatology) とは
- 心臓病学 心臓病学
- 双子研究 双子研究
背景:
- 以前の研究では,双子とシングルトンと比較して,モノコリアン双子の先天性心不全 (CHD) 率が高かったことが示唆されていた.
- 症例シリーズの報告はまた,双子の妊娠と心血管疾患の発生率の増加との潜在的な関連を示している.
研究 の 目的:
- シングレットと比べ,双子の大きなコホートで先天性心不全の発生を調査する.
- 双子における心血管疾患のリスクの増加が独角性双子に特異的であるかどうかを判断する.
主な方法:
- デンマークの双子の登録簿と統計局のデンマークの登録簿 (1977-2001年のデータ) (国立医療出生登録簿とデンマーク国立患者登録簿を含む) を利用した.
- 双子の個体41,525個,シングルトンの個体74,473個に関するデータを分析し,2006年まで追跡した.
- 入院患者または手術を受けた症例のみを含む感受性分析を実施しました.
主要な成果:
- 双子では,シングルと比べて心臓病のリスクが63%増加 (1.4%対0.87%) であった.
- 特許ドクトゥス・アテリオサスや大動脈の縮などの特定の心血管疾患は,双子の3倍以上の頻度で発生しました.
- 二胞胎 (二胞胎) の双子では,心血管疾患の発生率の増加が観察され,リスクが単胞胎妊娠に限定されていないことを示しています.
結論:
- 生まれながらの心欠陥は,シングルテンの場合よりも,双子に顕著に多く見られます.
- 双子の心血管疾患のリスクの増加は,胆管性とは無関係です.
- 胎内モニタリングと出生後の心臓の評価を,すべての双子に対して,体性や体性に関係なく推奨する.
関連する概念動画
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Nondisjunction
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Nondisjunction
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
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