ボーダーライン高血圧における筋交感神経の活性に対するバロレフレクスの制御
Circulation
|September 1, 1990
まとめ
境界性高血圧の患者は,加強された心肺気圧反射により,静止性ストレス中に交感性神経の活動が増加することを示しています. この反応は,動脈バロレフレクスの機能の障害と関連していない.
科学分野:
- 心血管生理学 心血管の生理学
- 高血圧の研究 高血圧の研究
- 自律神経系の機能 自律神経系の機能
背景:
- 境界性高血圧は,矯正的ストレスに対する過剰な血管反応と関連しています.
- 既存の理論によると,これらの患者では,心肺気圧受容体の活性が増加し,動脈気圧反射の潜在的障害があることが示唆されています.
研究 の 目的:
- オーソスタティック・ストレスの際の境界性高血圧における心肺動脈バロレフレクスの役割を調査する.
- 増加した心肺気圧反射運動が,動脈気圧反射機構の障害による二次性であるかどうかを判断する.
主な方法:
- 境界性高血圧および正常血圧の被験者における筋肉交感神経活動 (SNA) の記録.
- 静止性ストレスをシミュレートするために下部体負圧 (LBNP) を適用します.
- 動脈バロレフレクスの機能を評価するためにフェニルフリンとニトロプロシドを投与.
主要な成果:
- 境界性高血圧の被験者は,正常血圧の対照群と比較して,LBNPの間にSNAの有意な増加を示しました.
- 極限高血圧の被験者において,心肺動脈のバロレフレクスの増幅が増加した.
- 血圧の変化に対するSNA反応によって評価された動脈のバロレフレクスの機能は,グループ間で類似していました.
結論:
- 交感神経活動に対する心肺気圧反射制御は,境界性高血圧の個体において強化される.
- この心肺動脈のバルオレフレクスの増幅は,動脈のバルオレフレクスの機能とは独立している.
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