早期出産の若年成人における右心房シストリック機能障害
Adam J Lewandowski1, William M Bradlow, Daniel Augustine
1Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX39DU, UK.
Circulation
|August 14, 2013
まとめ
早期出産した若者は,右心室の構造と機能が変化している. 早期出産は右心室のサイズが小さくなり,質量が増加し,シストリック機能に影響を及ぼします.
科学分野:
- 心臓病学 心臓病学
- ネオナトロジーの新生児科
- ペディアトリック・カルディオロジー
背景:
- 早産は心血管の発達に影響し,若い成人では左心房の違いが知られている.
- 動物の研究では,早産後の両心室の心臓筋細胞の変化が示されています.
研究 の 目的:
- 早期出産した若い成人の右心室の構造と機能の違いを調査する.
- 右心室の変化を,以前に報告された左心室の変化と比較するために.
主な方法:
- 心血管磁気共鳴画像 (1.5-Tスキャナー) を用いて,早産児102人,受精児132人を評価した.
- 後処理ソフトウェア (Argus,TomTec) は,右心室のサイズ,質量,射出分数を定量化しました.
主要な成果:
- 早期出産の成人は,右心房が小さかった (終盤腹動体積) が,対照群と比較して右心房の質量が大きかった.
- 右心室の差異は,左心室で以前に観察されたものよりも顕著でした.
- 早期出産の成人では,右心房下部エジェクション分子が著しく低いことが発見され,一部では収縮機能不全が認められた.
結論:
- 胎児の早産は,成人期まで続く全般的な心筋の構造的,機能的な変化と関連しています.
- 右心室の大きさはより小さく,質量は早産の成人ではより大きく,潜在的に有意な収縮機能障害があります.
- これらの発見は,右心室における早産の長期的な心血管疾患の影響を強調しています.
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