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Updated: May 8, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

機能的に非対称なRAFキナーゼジメールのアロステリック活性化

Jiancheng Hu1, Edward C Stites2, Haiyang Yu2

  • 1Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Box 8118, St. Louis, MO 63110, USA; Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid, Box 8118, St. Louis, MO 63110, USA.

Cell
|September 3, 2013
PubMed
まとめ

RAFキナーゼは細胞の成長を制御し,その活性化には,キナーゼが他のキナーゼを活性化する非対称的二元体が含まれています. このプロセスはN端のリン酸化を必要とし,構成的に活性な突然変異体として設計することができます.

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Bioluminescence Resonance Energy Transfer (BRET)-Based Assay for Measuring Interactions of CRAF with 14-3-3 Proteins in Live Cells

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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

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