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Updated: May 1, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

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カストレーション耐性前立腺がんにおけるDHT合成における機能獲得変異

Kai-Hsiung Chang1, Rui Li2, Barbara Kuri3

  • 1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Division of Hematology/Oncology, Department of Internal Medicine and Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|September 3, 2013
PubMed
まとめ

カストレーション耐性前立腺がん (CRPC) は,3β-ヒドロキシステロイド脱水素酶1型 (3βHSD1) の変異を発症し,二酸化テストステロン (DHT) 産生の増加と腫瘍の成長につながる可能性があります. 3βHSD1を標的にすることは,CRPCに対する新しい治療戦略を提供することができる.

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A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

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Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses08:36

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Transduction01:16

Transduction

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