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Updated: May 8, 2026

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
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In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

Usp16は,ダウン症候群における体幹細胞の欠陥に寄与する.

Maddalena Adorno1, Shaheen Sikandar, Siddhartha S Mitra

  • 1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature
|September 13, 2013
PubMed
まとめ

ダウン症候群のモデルにおけるUsp16のトリプリケーションは,細胞再生を阻害し,早期老化を引き起こします. Usp16レベルを低下させると,これらの欠陥は大きく逆転し,ダウン症候群の病理学的治療目標としてUsp16が示唆されます.

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