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Updated: May 8, 2026

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
12:12

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors

Published on: December 17, 2013

in vivoでの再プログラムにより,トーティポテンシー特性を有するテラトーマとiPS細胞が生成されます

María Abad1, Lluc Mosteiro, Cristina Pantoja

  • 1Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid E-28029, Spain.

Nature
|September 13, 2013
PubMed
まとめ

誘導性多能幹細胞 (iPS細胞) は,生物体内で生成される (in vivo再プログラム). これらの細胞はトーティポテンシー特性を発揮し,再生医療に新たな道を開く.

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
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