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酸化されたCa2+) /カルモジュリン依存タンパク質キナーゼIIは心房細動を誘発する

Anil Purohit1, Adam G Rokita, Xiaoqun Guan

  • 1Department of Internal Medicine, Division of Cardiovascular Medicine and Cardiovascular Research Center, Carver College of Medicine (A.P., A.G.R., X.G., B.C., O.M.K., Z.G., E.D.L., H.S., A.C.B., R.N.E.-A., P.D.S., R.M.W., L.-S.S., M.E.A.), Department of Obstetrics and Gynecology (B.Y.), and Department of Molecular Physiology and Biophysics (M.E.A.), University of Iowa, Iowa City; Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (N.V., D.D.); Cardiology and Pneumology, German Heart Center, University Hospital Goettingen, Goettingen, Germany (S.N., T.S., L.S.M.); and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX (N.L., X.H.T.W.).

Circulation
|September 14, 2013
PubMed
まとめ

酸化されたCa2+/カルモジュリン依存タンパク質キナーゼII (CaMKII) は心房細動 (AF) と関連しています. 酸化したCaMKIIを減少させることで,AF患者の新しい治療法を提供することができる.

キーワード:
アンジオテンシンIIアリズム障害,心臓動脈不全など.動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈カルシウムカルモジュリン依存型タンパク質キナーゼII型反応性酸素種に反応する.

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