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Updated: May 7, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

酵素結合メタボリットの生化学的決定:プログラムされたオクタケチドがエネダイネポリケチド合成酵素CalE8に優先的に蓄積される

Katherine Belecki1, Craig A Townsend

  • 1Department of Chemistry, The Johns Hopkins University , Remsen 252, 3400 North Charles St., Baltimore, Maryland 21218, United States.

Journal of the American Chemical Society
|September 18, 2013
PubMed
まとめ

研究者らは,抗生物質の生物合成における酵素結合中間物質の放出と分析のための軽度な化学的方法を開発した. これらの技術は,カリケアミシン生産における重要なオクタケチド前駆体を特定し,エネディイン抗生物質の組成に関する理解を深めました.

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