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ソマティック細胞の決定的直接再プログラミングにより,多能性を獲得する.

Yoach Rais1, Asaf Zviran, Shay Geula

  • 1The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.

Nature
|September 20, 2013
PubMed
まとめ

体細胞を誘発性多能幹細胞 (iPS) に再プログラムすることは,典型的には非効率です. Mbd3を減量すると,Oct4,Sox2,Klf4,Myc (OSKM) の再プログラムがほぼ100%の効率に向上し,決定的で同期されたプロセスを生み出します.

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