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Updated: May 7, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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構成的なμ-オピオイド受容体活性により,長期的な内生性鎮痛症と依存性が生じます

G Corder1, S Doolen, R R Donahue

  • 1Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.

Science (New York, N.Y.)
|September 21, 2013
PubMed
まとめ

組織損傷はμ-オピオイド受容体 (MORs) を活性化し,長期的な疼痛緩和を提供します. この活動をブロックすると,オピオイド離脱症状が発生し,MORが慢性疼痛の発症を予防することを示唆しています.

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