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Updated: May 7, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
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Published on: June 27, 2025

肺動脈高血圧の患者における右心室ダイアストリック機能障害

Silvia Rain1, M Louis Handoko, Pia Trip

  • 1Departments of Pulmonology (S.R., P.T., C.T.-J.G., N.W., P.E.P., A.V.-N., F.S.d.M.), Physiology (S.R., M.L.H., N.W., G.J.S., W.J.P., C.A.C.O., J.v.d.V., F.S.d.M.), Cardiology (M.L.H.), and Medical Physics (J.T.M.), VU University Medical Center/Institute for Cardiovascular Research, Amsterdam, the Netherlands; Université Paris-Sud, Le Kremlin-Bicêtre, France (P.D., C.G., M.H.); INSERM UMR 999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France (P.D., C.G., M.H.); AP-HP, Hôpital de Bicêtre, Service de Pneumologie, DHU Thorax Innovation, Le Kremlin-Bicêtre, France (M.H.); Heart & Lung Transplant Unit, St. Vincent's Hospital and Victor Chang Cardiac Research Institute, Sydney, Australia (P.M.); Muscle Research Unit, Institute for Biomedical Research, University of Sydney, Sydney, Australia (C.d.R.); Sarver Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona, Tucson (C.S., C.G.H., H.L.G.); and ICIN-The Netherlands Heart Institute, Utrecht, the Netherlands (J.v.d.V.).

Circulation
|September 24, 2013
PubMed
まとめ

右心室のダイアストリック硬さは,肺動脈高血圧 (PAH) で上昇し,コラーゲンの増加と心臓筋細胞内の硬化したサルコメアによって引き起こされます. この発見は,PAHの進行のメカニズムを明確にします.

キーワード:
ディアストロリー (diastole) とは心不全は,心不全によって引き起こされる.高血圧,肺動脈高血圧などです.サルコメレスはサルコメレスです.

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