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Updated: May 7, 2026

Generation of Maternal Mutants Using zpc:cas9 Knock-in Zebrafish
09:17

Generation of Maternal Mutants Using zpc:cas9 Knock-in Zebrafish

Published on: July 22, 2025

ナノグ,Pou5f1,SoxB1は,母体から子体への移行中にジゴティック遺伝子発現を活性化します

Miler T Lee1, Ashley R Bonneau, Carter M Takacs

  • 11] Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA [2].

Nature
|September 24, 2013
PubMed
まとめ

母性ナノグ,Pou5f1 (Oct4),SoxB1の転写因子は,ゼブラフィッシュのジゴティックゲノム活性化 (ZGA) を開始する. 欠乏すると,発育が停止し,母から子宮への移行 (MZT) に不可欠なmiR-430を含む重要な遺伝子の活性化が妨げられます.

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