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関連する概念動画

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...

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Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells
06:42

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Published on: May 24, 2024

セルフ生成のケモカイン・グラデントによる方向性組織移動.

Erika Donà1, Joseph D Barry, Guillaume Valentin

  • 1EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany.

Nature
|September 27, 2013
PubMed
まとめ
この要約は機械生成です。

移動する細胞集団は,外部信号から独立して移動し,独自の局所的な誘導信号を作成することができます. この自己生成したケモカイン・グラデーションメカニズムは,体内での組織移動を指揮する.

さらに関連する動画

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

関連する実験動画

Last Updated: May 7, 2026

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells
06:42

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Published on: May 24, 2024

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

科学分野:

  • 発達生物学 発達生物学とは
  • 細胞生物学 細胞生物学
  • 分子生物学は分子生物学である.

背景:

  • 胚形成は,指向された細胞移動に依存し,通常は外部の化学誘導物質のグラデーションに沿って行われる.
  • 移動するローカル・グラデーションの自己生成は,自己決定の方向性を可能にすることで,代替的な移住戦略を提供します.
  • 内生的な誘導信号のインビボ可視化は,自己生成のグラデーションを研究する上で大きな制限となっている.

研究 の 目的:

  • 光タイマーアプローチを用いて,キモカインCxcl12aのインビボ動態を定義する.
  • 移動する細胞集団が自己生成したケモカインのグラデーションを in vivo で生成できることを示すため.
  • 局所細胞外シューシェーピングによる自己指向の組織移動のインビボ証拠を提供するため.

主な方法:

  • 生きたゼブラフィッシュのリガンド誘発受容体周回数を測定するために,光タイマーアプローチを使用しました.
  • この方法をゼブラフィッシュの横線原始モデルシステムに適用しました.
  • 非典型受容体Cxcr7の外部源を設計して,自己生成のグラデーションの十分性をテストしました.

主要な成果:

  • 誘導分子のCxcl12a.a.の量化されたインビボダイナミクス
  • 移転する細胞集団が,極化受容体媒介の内部化を介して,自己生成のケモカイン活性グラデーションを生成することを示した.
  • 自発的に生成されたグラデントメカニズムが,堅固な集団細胞移動を誘導するのに十分であることを実証した.

結論:

  • この研究は,細胞外シグネルの局所的形成によって誘導される自己指向の組織移動に対する最初のin vivo証拠を提供します.
  • この発見は,遠距離グラデーションとは無関係な集団的な細胞移動のための新しいメカニズムを明らかにしています.
  • 開発過程における自己指向の移住と,がんの侵入のような病気を調査するための枠組みを確立する.