横部下垂体における阻害回路構造は,餌をオーケストラ化する

Joshua H Jennings¹, Giorgio Rizzi, Alice M Stamatakis

¹Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Science (New York, N.Y.)

|September 28, 2013

まとめ

脳のニューラル回路は,

科学分野:

神経科学は神経科学である.
行動神経科学は,行動神経科学である.
神経生物学神経生物学とは

背景:

過食障害は,世界的な肥満の流行に大きく貢献しています.
機能不全の神経回路は,異常な食事行動に関与しています.
横部下垂体 (LH) は,動機付けられた食事行動において重要な役割を果たします.

研究の目的:

栄養における横向下垂体 (LH) のニューロンの活動を制御する正確な機能神経回路を定義する.
LHニューロンと食物の摂取を調節する拡張杏仁の役割を調査する.

主な方法:

側下垂体における電気生理学的記録.
In vivo 神経回路の追跡と操作.
LHグルタマタージックニューロンへのシナプス入力分析.

主要な成果:

拡張された桃体からの阻害性シナプスインプットは,好ましく LH グルタマタージックニューロン活動を刺激し,抑制することが判明しました.
拡張された桃体によるLHニューロンの抑制は,食物の摂取を制御する上で重要な役割を果たします.

結論:

拡張された桃体は,栄養を調節するために,横向下垂体 (LH) のグルタマタージックニューロンに抑制的な制御を行います.
拡張杏仁とLHを巻き込んだこの神経ネットワーク内の調節不全は,適応不良の食事につながり,肥満に寄与する可能性があります.

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