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関連する概念動画

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Distribution of Cytoplasmic Content02:33

Distribution of Cytoplasmic Content

Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...
Eukaryotic Compartmentalization01:37

Eukaryotic Compartmentalization

One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
Eukaryotic Compartmentalization01:46

Eukaryotic Compartmentalization

One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...

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関連する実験動画

Updated: May 7, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

G1区分化と細胞運命を調整する.

Stephen Dalton1

  • 1Department of Biochemistry and Molecular Biology, Paul D. Coverdell Center for Biomedical and Health Sciences, The University of Georgia, 500 DW Brooks Drive, Athens, GA 30602, USA.

Cell
|October 1, 2013
PubMed
まとめ

細胞サイクル進行は幹細胞の運命を左右する. G1後半のサイクリンDはTGF-βシグナル伝達を制限し,多能幹細胞を内皮から神経内皮の分化に切り替えます.

科学分野:

  • 幹細胞生物学 幹細胞生物学とは
  • 細胞サイクル調節 細胞サイクル調節
  • 発達生物学 発達生物学とは

背景:

  • 多能幹細胞は,様々な細胞型に微分化することができる.
  • TGF-βのような細胞シグナル伝達経路は,分化を調節する.
  • 系統の仕様における細胞サイクルの役割は,完全に理解されていません.

研究 の 目的:

  • 細胞周期が多能幹細胞の分化可能性にどのように影響するかを調査する.
  • TGF-β依存分化におけるサイクリンDの役割を決定する.
  • 細胞サイクル,シグナル伝達,系統選択の間の連携を理解する.

主な方法:

  • 活用された多能幹細胞.
  • 操作された細胞サイクルフェーズ (G1).
  • 評価されたTGF-βシグナル伝達経路活性 (Smad2/3).
  • 分析された系統の仕様 (内皮と神経内皮).

主要な成果:

  • 初期のG1段階では,TGF-β誘発の内皮分化が許容される.
  • G1後半のサイクリンDは,Smad2/3の活動を制限する.

さらに関連する動画

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

関連する実験動画

Last Updated: May 7, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

  • この制限は,細胞ポテンシャルを内皮から神経内皮に切り替える原因となります.

    • 結論:

    • 細胞サイクル段階,特にG1後半のサイクリンD活動は,幹細胞系統の可能性を決定する重要な決定因子です.
    • 細胞サイクル進行とTGF-βのようなシグナル伝達経路の連携が,分化結果を支配する.
    • 発見は,幹細胞における細胞サイクル制御と発達上の決定の間のメカニズム的リンクを提供している.