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Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

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関連する実験動画

Updated: May 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

人間のエピジェノームのマッピング

Chloe M Rivera1, Bing Ren

  • 1Ludwig Institute for Cancer Research, Institute of Genomic Medicine, UCSD Moores Cancer Center, University of California School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA; The Biomedical Sciences Graduate Program, Institute of Genomic Medicine, UCSD Moores Cancer Center, University of California School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA.

Cell
|October 1, 2013
PubMed
まとめ
この要約は機械生成です。

エピゲノムマップは,細胞特有の情報を明らかにし,遺伝子調節と発達の理解を助けます. このレビューは,表遺伝子のマッピングツールと,DNAメチル化とクロマチンの構造分析におけるその応用をカバーしています.

さらに関連する動画

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
08:04

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

関連する実験動画

Last Updated: May 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
08:04

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

科学分野:

  • ゲノミクスとエピジェノミクス
  • 分子生物学は分子生物学である.
  • 細胞生物学 細胞生物学

背景:

  • エピゲノムはゲノムとは異なり,細胞特有の重要な情報を保持しています.
  • 高通量技術の進歩により,広範なヒトの表遺伝子のマッピングが可能になりました.

研究 の 目的:

  • 現在のエピゲノムマッピングツールキットをレビューする.
  • 遺伝子調節と発達の理解において,エピゲノムマップの有用性を議論する.
  • エピジェノミクス分野における進歩と課題を強調する.

主な方法:

  • DNAメチル化のためのマッピング技術に焦点を当てます.
  • クロマチンの変異状態の分析.
  • クロマチンの構造の特徴.

主要な成果:

  • エピゲノムマップは,ヒトの遺伝子調節配列を特定するのに役立ちます.
  • これらのマップは,複雑な開発プログラムを定義するのに役立ちます.
  • 現在のツールは,細胞タイプ間の表遺伝的多様性についての洞察を提供します.

結論:

  • エピゲノムマッピングは急速に進歩する分野であり,生物学と医学に重大な影響を及ぼします.
  • 既存の課題を克服し,エピジェノミックデータを完全に利用するためにさらなる研究が必要です.
  • エピゲノムマップは,細胞のアイデンティティと機能を解読するための強力なリソースを提供します.